Panama Canal Luxury Cruises

Browse all available sailing dates for luxury cruise holidays to the Panama Canal. To find out more and to discover the best deals call us today and speak to our cruise experts. All Pnama Canal cruise holidays are fully ABTA & ATOL protected.

Find Out More About Panama Canal Cruising


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18-Day Panama Canal Passage
Miami, Florida | Cartagena | Puntarenas | Puerto Quetzal | Puerto Chiapas | Huatulco (Santa María Huatulco) | Cabo San Lucas | Los Angeles, California
09 Nov 2024
18 Nights
Seabourn Quest
Panama Canal
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
Save up to 30%*
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £8785pp
Now: £5357 pp
REF: SBN6467
Panama Canal Voyage with Panama Stay
Miami, Florida | Oranjestad | Kralendijk | Willemstad | Cartagena | Fuerte Amador | Fuerte Amador
02 Dec 2024
15 Nights
Azamara Journey
Panama Canal
FLASH SALE - up to an ADDITIONAL $250 to spend on-board ENDS 22d September
Hidden Gems Sale - $500 to spend on board | Book a Veranda or Suite to get unlimited Wi-Fi or a Premium Beverage Package
Two-night luxury hotel stay included when booking with SixStarCruises
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
HOLIDAY PRICES FROM
Was £3699pp
Now: £3389 pp
REF: AZJR10C013-031224-2

Cruise & Stay

11 Night Panama Canal & S Caribbean
Fort Lauderdale, Florida | Cartagena | Colón | Oranjestad | Kralendijk | Georgetown, Grand Cayman | Fort Lauderdale, Florida
02 Dec 2024
11 Nights
Celebrity Beyond
Panama Canal
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £3051pp
Now: £2898 pp
REF: CELEBBY11C017-021224
10-Night Ceo Loyalty Panama Canal Voyage
Miami, Florida | Oranjestad | Kralendijk | Willemstad | Cartagena | Fuerte Amador | Fuerte Amador
03 Dec 2024
10 Nights
Azamara Journey
Panama Canal
FLASH SALE - up to an ADDITIONAL $250 to spend on-board ENDS 22d September
Hidden Gems Sale - $500 to spend on board | Book a Veranda or Suite to get unlimited Wi-Fi or a Premium Beverage Package
Two-night luxury hotel stay included when booking with SixStarCruises
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £2662pp
Now: £2211 pp
REF: AZJR10C013-031224
Western Caribbean Bliss
Miami, Florida | Costa Maya | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Colón | Cartagena | Cartagena
03 Dec 2024
10 Nights
Oceania Nautica
Caribbean
FREE simply MORE shore excursion credit, FREE gratuities, FREE Champagne, wine and more, FREE speciality dining and FREE Wi-Fi available on EVERY booking
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £2979pp
Now: £2688 pp
REF: OCEANIANAU241203
Caribbean Panorama
Miami, Florida | Costa Maya | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Colón | Cartagena | Cartagena | Santa Marta | Oranjestad | Willemstad | Castries | Gustavia | More...
03 Dec 2024
20 Nights
Oceania Nautica
Caribbean
FREE simply MORE shore excursion credit, FREE gratuities, FREE Champagne, wine and more, FREE speciality dining and FREE Wi-Fi available on EVERY booking
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £4299pp
Now: £3879 pp
REF: OCEANIANAU241203A
South America Kaleidoscope
Miami, Florida | Costa Maya | Harvest Caye | Roatán Island | Puerto Limón | Panama City | Panama City | Manta | Salaverry | Callao | Callao | Pisco | Coquimbo | San Antonio | More...
07 Dec 2024
50 Nights
Oceania Marina
South America
FREE simply MORE shore excursion credit, FREE gratuities, FREE Champagne, wine and more, FREE speciality dining and FREE Wi-Fi available on EVERY booking
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £13369pp
Now: £12065 pp
REF: OCEANIAMNA241207B
Maya & Inca Discovery
Miami, Florida | Costa Maya | Harvest Caye | Roatán Island | Puerto Limón | Panama City | Panama City | Manta | Salaverry | Callao | Callao
07 Dec 2024
14 Nights
Oceania Marina
South America
FREE simply MORE shore excursion credit, FREE gratuities, FREE Champagne, wine and more, FREE speciality dining and FREE Wi-Fi available on EVERY booking
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £5929pp
Now: £5350 pp
REF: OCEANIAMNA241207
Sunlit Strands & Icy Lands
Miami, Florida | Costa Maya | Harvest Caye | Roatán Island | Puerto Limón | Panama City | Panama City | Manta | Salaverry | Callao | Callao | Pisco | Coquimbo | San Antonio | More...
07 Dec 2024
38 Nights
Oceania Marina
World-wide
FREE simply MORE shore excursion credit, FREE gratuities, FREE Champagne, wine and more, FREE speciality dining and FREE Wi-Fi available on EVERY booking
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £12169pp
Now: £10982 pp
REF: OCEANIAMNA241207A
EXCLUSIVE OFFER - Panama City Stay with Panama Canal Voyage
Fuerte Amador | Puerto Limón | Roatán Island | Santo Tomás de Castilla | Costa Maya | Cozumel | Miami, Florida
09 Dec 2024
14 Nights
Azamara Journey
Panama Canal
FLASH SALE - up to an ADDITIONAL $250 to spend on-board ENDS 22d September
Hidden Gems Sale - $500 to spend on board | Book a Veranda or Suite to get unlimited Wi-Fi or a Premium Beverage Package
Two-night luxury hotel stay included when booking with SixStarCruises
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
HOLIDAY PRICES FROM
Was £2769pp
Now: £2569 pp
REF: AZJR241213-009-2

Cruise & Stay

Tropical Holiday
Miami, Florida | Georgetown, Grand Cayman | Cartagena | Puntarenas | Corinto | Puerto Quetzal | Acapulco | Cabo San Lucas | Ensenada | Los Angeles, California
13 Dec 2024
16 Nights
Seven Seas Grandeur
Panama Canal
Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £9549pp
Now: £9071 pp
REF: REGENTGRA241213
9-Night Panama Canal Voyage
Fuerte Amador | Puerto Limón | Roatán Island | Santo Tomás de Castilla | Costa Maya | Cozumel | Miami, Florida
13 Dec 2024
9 Nights
Azamara Journey
Panama Canal
FLASH SALE - up to an ADDITIONAL $250 to spend on-board ENDS 22d September
Hidden Gems Sale - $500 to spend on board | Book a Veranda or Suite to get unlimited Wi-Fi or a Premium Beverage Package
Two-night luxury hotel stay included when booking with SixStarCruises
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £2472pp
Now: £1832 pp
REF: AZJR241213-009
Fort Lauderdale to Los Angeles
Fort Lauderdale, Florida | Cartagena | Cartagena | Panama City | Puntarenas | Cabo San Lucas | San Diego, California | Los Angeles, California
17 Dec 2024
18 Nights
Silver Shadow
Caribbean
Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £10000pp
Now: £9025 pp
REF: SILVERSS241217018
Fort Lauderdale to Fuerte Amador
Fort Lauderdale, Florida | Cartagena | Cartagena | Panama City
17 Dec 2024
7 Nights
Silver Shadow
Caribbean
Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £13450pp
Now: £5368 pp
REF: SILVERSS241217S07
17-Night Panama Canal Holiday
Miami, Florida | Cartagena | Cartagena | Puntarenas | Puerto Quetzal | Ixtapa/Zihuatanejo | Cabo San Lucas | San Diego, California | San Diego, California
20 Dec 2024
17 Nights
Azamara Onward
Panama Canal
FLASH SALE - up to an ADDITIONAL $250 to spend on-board ENDS 22d September
Hidden Gems Sale - $500 to spend on board | Book a Veranda or Suite to get unlimited Wi-Fi or a Premium Beverage Package
Amazing prices you just cant miss - very limited availability at these prices
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £5209pp
Now: £4901 pp
REF: AZON17C015-201224
Mangroves Of The Maya
Miami, Florida | Costa Maya | Harvest Caye | Roatán Island | Puerto Limón | Colón | Cartagena | Willemstad | Oranjestad | Castries | Bridgetown
21 Dec 2024
14 Nights
Oceania Sirena
Caribbean
Receive up to a four-category stateroom upgrade*!
FREE simply MORE shore excursion credit, FREE gratuities, FREE Champagne, wine and more, FREE speciality dining and FREE Wi-Fi available on EVERY booking
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £5189pp
Now: £3930 pp
REF: OCEANIASIR241221
Bridgetown to Fort Lauderdale
Bridgetown | Scarborough | Castries | Port Elizabeth, Bequia | Willemstad | Oranjestad | Cartagena | Cartagena | Colón | Roatán Island | Belize City | Cozumel | Fort Lauderdale, Florida
21 Dec 2024
16 Nights
Silver Moon
Caribbean
$300 FREE to spend on-board - ONLY when booking with SixStarCruises
Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £9300pp
Now: £8393 pp
REF: SILVERMO241221016
11 Night Canal & Caribbean Holiday
Fort Lauderdale, Florida | Cartagena | Colón | Willemstad | Oranjestad | Georgetown, Grand Cayman | Fort Lauderdale, Florida
23 Dec 2024
11 Nights
Celebrity Beyond
Panama Canal
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £5328pp
Now: £5061 pp
REF: CELEBBY11C018-231224
Beyond The Panama Canal
Miami, Florida | Great Stirrup Cay | Cartagena | Puntarenas | Corinto | Puerto Quetzal | Acapulco | Cabo San Lucas | Ensenada | Los Angeles, California
23 Dec 2024
16 Nights
Oceania Nautica
Panama Canal
Olife Choice AVAILABLE ON EVERY BOOKING - $800 to spend on-board OR 8 FREE shore excursions or FREE beverage package
HUGE savings, FREE pre-paid gratuities worth up to $23pppd & FREE on-board spend - EXCLUSIVE to SixStarCruises
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £4459pp
Now: £3537 pp
REF: OCEANIANAU241223
Fuerte Amador to Los Angeles
Panama City | Puntarenas | Cabo San Lucas | San Diego, California | Los Angeles, California
24 Dec 2024
11 Nights
Silver Shadow
Caribbean
Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £5050pp
Now: £4557 pp
REF: SILVERSS241224S11
Cartagena to Fort Lauderdale
Cartagena | Cartagena | Colón | Roatán Island | Belize City | Cozumel | Fort Lauderdale, Florida
29 Dec 2024
8 Nights
Silver Moon
Caribbean
Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £5650pp
Now: £5099 pp
REF: SILVERMO241229S08
South America and the Panama Canal - Lima to Fort Lauderdale
Callao | Callao | Guayaquil | Panama City | Cartagena | Cartagena | Oranjestad | Fort Lauderdale, Florida
04 Jan 2025
16 Nights
Silver Ray
South America
$300 FREE to spend on-board - ONLY when booking with SixStarCruises
Limited time 10% savings included
Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £8400pp
Now: £5577 pp
REF: SILVERRA250104016
Lima to Fuerte Amador
Callao | Callao | Guayaquil | Panama City
04 Jan 2025
7 Nights
Silver Ray
South America
Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £3000pp
Now: £2707 pp
REF: SILVERRA250104S07
Fort Lauderdale to Lima (Callao)
Fort Lauderdale, Florida | Georgetown, Grand Cayman | Costa Maya | Belize City | Roatán Island | Cartagena | Cartagena | Fuerte Amador | Manta | Guayaquil | Guayaquil | Salaverry | Callao
07 Jan 2025
18 Nights
Crystal Serenity
Caribbean
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £7550pp
Now: £7323 pp
REF: CRYSTALCSE-018-250107
Ft. Lauderdale to Barcelona
Fort Lauderdale, Florida | Georgetown, Grand Cayman | Costa Maya | Belize City | Roatán Island | Cartagena | Cartagena | Fuerte Amador | Manta | Guayaquil | Guayaquil | Salaverry | Callao | Callao | More...
07 Jan 2025
123 Nights
Crystal Serenity
World-wide
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £54400pp
Now: £52768 pp
REF: CRYSTALCSE-W122-250107

Prices are subject to change and availability. Prices may vary depending on airport selected. Promotions are only applicable to select cabins grades, please call for details

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