Panama Canal Luxury Cruises

Browse all available sailing dates for luxury cruise holidays to the Panama Canal. To find out more and to discover the best deals call us today and speak to our cruise experts. All Pnama Canal cruise holidays are fully ABTA & ATOL protected.

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42-Day Panama Canal & Hawaiian Holiday
Miami, Florida | Catalina Island | Curaçao | Santa Marta | Golfito | Puntarenas | Puerto Quetzal | Puerto Chiapas | Huatulco (Santa María Huatulco) | Cabo San Lucas | Los Angeles, California | Honolulu, Hawaii | Honolulu, Hawaii | Hilo, Hawaii | More...
25 Nov 2025
42 Nights
Seabourn Sojourn
Panama Canal
EXCLUSIVE $300 to spend on-board* - must end 29th October 2024
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
Cruise Only From
Was £15168pp
Now: £14257 pp
REF: SBN5563A
Palms To Andean Peaks
Miami, Florida | Cozumel | Costa Maya | Belize City | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Panama City | Manta | Guayaquil | Salaverry | Callao | More...
29 Nov 2025
22 Nights
Oceania Marina
South America
Bonus Savings Sale - Save up to 30%*
Your World Included - FREE gratuities, FREE gourmet speciality dining, FREE unlimited Wi-Fi and FREE soft drinks including speciality teas & coffees
Fly Cruise From
Was £5815pp
Now: £5524 pp
REF: OCEANIAMNA251129
Iconic Isles To Icebergs
Miami, Florida | Cozumel | Costa Maya | Belize City | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Panama City | Manta | Guayaquil | Salaverry | Callao | More...
29 Nov 2025
42 Nights
Oceania Marina
South America
Bonus Savings Sale - Save up to 30%*
Your World Included - FREE gratuities, FREE gourmet speciality dining, FREE unlimited Wi-Fi and FREE soft drinks including speciality teas & coffees
Fly Cruise From
Was £9811pp
Now: £9320 pp
REF: OCEANIAMNA251129A
Odyssey To World's End
Miami, Florida | Cozumel | Costa Maya | Belize City | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Panama City | Manta | Guayaquil | Salaverry | Callao | More...
29 Nov 2025
54 Nights
Oceania Marina
World-wide
Bonus Savings Sale - Save up to 30%*
Your World Included - FREE gratuities, FREE gourmet speciality dining, FREE unlimited Wi-Fi and FREE soft drinks including speciality teas & coffees
Fly Cruise From
Was £11758pp
Now: £11170 pp
REF: OCEANIAMNA251129B
38-Day Panama Canal Passage & Pacific Crossing
Miami, Florida | Bonaire | Curaçao | Cartagena | Fuerte Amador | Fuerte Amador | Puntarenas | Puerto Chiapas | Puerto Vallarta | Honolulu, Hawaii | Honolulu, Hawaii | Lihue, Kauai Island, Hawaii | Tokyo
02 Dec 2025
38 Nights
Seabourn Encore
Panama Canal
EXCLUSIVE $300 to spend on-board* - must end 29th October 2024
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
Cruise Only From
Was £10542pp
Now: £9909 pp
REF: SBN7590B
46-Day Panama Canal Passage & Pacific Crossing
Miami, Florida | Bonaire | Curaçao | Cartagena | Fuerte Amador | Fuerte Amador | Puntarenas | Puerto Chiapas | Puerto Vallarta | Honolulu, Hawaii | Honolulu, Hawaii | Lihue, Kauai Island, Hawaii | Tokyo | Osaka | More...
02 Dec 2025
46 Nights
Seabourn Encore
Panama Canal
EXCLUSIVE $300 to spend on-board* - must end 29th October 2024
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
Cruise Only From
Was £13049pp
Now: £12266 pp
REF: SBN7590C
10-Day Caribbean & Panama Canal Passage
Miami, Florida | Bonaire | Curaçao | Cartagena | Fuerte Amador | Fuerte Amador
02 Dec 2025
10 Nights
Seabourn Encore
Caribbean
EXCLUSIVE $300 to spend on-board* - must end 29th October 2024
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
Cruise Only From
Was £3059pp
Now: £2875 pp
REF: SBN7590
27-Day Caribbean, Panama Canal Passage & Hawaii
Miami, Florida | Bonaire | Curaçao | Cartagena | Fuerte Amador | Fuerte Amador | Puntarenas | Puerto Chiapas | Puerto Vallarta | Honolulu, Hawaii | Honolulu, Hawaii
02 Dec 2025
27 Nights
Seabourn Encore
Caribbean
EXCLUSIVE $300 to spend on-board* - must end 29th October 2024
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
Cruise Only From
Was £7019pp
Now: £6597 pp
REF: SBN7590A
A Tale Of Two Seas
Miami, Florida | Port Royal | Santa Marta | Cartagena | Puntarenas | San Juan del Sur | Acajutla | Puerto Quetzal | Huatulco (Santa María Huatulco) | Puerto Vallarta | Los Angeles, California
03 Dec 2025
17 Nights
Oceania Vista
Panama Canal
Bonus Savings Sale - Save up to 30%*
Your World Included - FREE gratuities, FREE gourmet speciality dining, FREE unlimited Wi-Fi and FREE soft drinks including speciality teas & coffees
Fly Cruise From
Was £7040pp
Now: £6688 pp
REF: OCEANIAVIS251203
28-Day Pacific Crossing & Treasures Of Japan
Fuerte Amador | Puntarenas | Puerto Chiapas | Puerto Vallarta | Honolulu, Hawaii | Honolulu, Hawaii | Lihue, Kauai Island, Hawaii | Tokyo
12 Dec 2025
28 Nights
Seabourn Encore
Pacific
EXCLUSIVE $300 to spend on-board* - must end 29th October 2024
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
Cruise Only From
Was £7109pp
Now: £6682 pp
REF: SBN7591A
36-Day Central America, Hawaiian Nights & Pacific Crossing
Fuerte Amador | Puntarenas | Puerto Chiapas | Puerto Vallarta | Honolulu, Hawaii | Honolulu, Hawaii | Lihue, Kauai Island, Hawaii | Tokyo | Osaka | Kochi | Keelung (Chilung) | Hong Kong
12 Dec 2025
36 Nights
Seabourn Encore
Pacific
EXCLUSIVE $300 to spend on-board* - must end 29th October 2024
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
Cruise Only From
Was £10349pp
Now: £9728 pp
REF: SBN7591B
17-Day Costa Rica, Mexico & Hawaiian Nights
Fuerte Amador | Puntarenas | Puerto Chiapas | Puerto Vallarta | Honolulu, Hawaii | Honolulu, Hawaii
12 Dec 2025
17 Nights
Seabourn Encore
Pacific
EXCLUSIVE $300 to spend on-board* - must end 29th October 2024
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
Cruise Only From
Was £4769pp
Now: £4482 pp
REF: SBN7591
11 Nt Panama Canal & Perfect Day Holiday
Fort Lauderdale, Florida | Cartagena | Colón | Oranjestad | Willemstad | Coco Cay | Fort Lauderdale, Florida
22 Dec 2025
11 Nights
Celebrity Ascent
Panama Canal
Fly Cruise From
Was £7969pp
Now: £7570 pp
REF: CELEBAT11C022-221225
Tropical Escape Across The Canal
Miami, Florida | Georgetown, Grand Cayman | Ocho Rios | Kralendijk | Willemstad | Oranjestad | Cartagena | Puerto Limón | Panama City | Puntarenas | Corinto | Puerto Vallarta | Cabo San Lucas | Ensenada | More...
03 Jan 2026
22 Nights
Seven Seas Grandeur
Caribbean
Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
Fly Cruise From
Was £12819pp
Now: £12178 pp
REF: REGENTGRA260103A
Majestic Beaches & Canal Crossing
Miami, Florida | Georgetown, Grand Cayman | Ocho Rios | Kralendijk | Willemstad | Oranjestad | Cartagena | Puerto Limón | Panama City
03 Jan 2026
12 Nights
Seven Seas Grandeur
Caribbean
Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
Fly Cruise From
Was £7989pp
Now: £7589 pp
REF: REGENTGRA260103
A Journey from Majestic Barrier Reefs to Mystical Jungle Ruins
Miami, Florida | San Andrés Island | Colón | Bocas del Toro | Puerto Limón | Georgetown, Grand Cayman | Miami, Florida
05 Jan 2026
10 Nights
Explora II
Caribbean
Enjoy a complimentary dinner at Anthology PLUS book with a low 10% deposit*
Cruise Only From
Was £4035pp
Now: £3833 pp
REF: EXPLORAEP20260105MIAMIA
79-Night Circle South America Grand Voyage
Miami, Florida | Saint John Island | Charlotte Amalie | Philipsburg | Charlestown | Saint John's | Saint Pierre | Port Elizabeth, Bequia | Saint George's | Bridgetown | Scarborough | Isle Royale | Belem | Recife | More...
06 Jan 2026
79 Nights
Azamara Quest
South America
Balconies and above receive: $300 FREE to spend on-board, Premium beverage package & unlimited wi-fi*
Cruise Only From
Was £23219pp
Now: £22290 pp
REF: AZQS260106-079
155-Night Azamara World Voyage
Miami, Florida | Progreso | Progreso | Puerto Limón | Fuerte Amador | Fuerte Amador | Manta | Guayaquil | Trujillo | Callao | Callao | Hangaroa, Easter Island | Hangaroa, Easter Island | Pitcairn Island | More...
06 Jan 2026
156 Nights
Azamara Onward
World-wide
Balconies and above receive: $300 FREE to spend on-board, Premium beverage package & unlimited wi-fi*
Cruise Only From
Was £36599pp
Now: £35135 pp
REF: AZON260106-155
15-Night Central America Tapestry Voyage
Miami, Florida | Progreso | Progreso | Puerto Limón | Fuerte Amador | Fuerte Amador | Manta | Guayaquil | Trujillo | Callao | Callao
06 Jan 2026
15 Nights
Azamara Onward
Panama Canal
Balconies and above receive: $300 FREE to spend on-board, Premium beverage package & unlimited wi-fi*
Cruise Only From
Was £4119pp
Now: £3954 pp
REF: AZON260106-015
Fort Lauderdale to Lima
Fort Lauderdale, Florida | Cozumel | Puerto Limón | Colón | Manta | Callao | Callao
06 Jan 2026
13 Nights
Silver Dawn
South America
Save £2400 per couple
Fly Cruise From
Was £11450pp
Now: £10877 pp
REF: SILVERDA260106013
Southampton to Los Angeles
Southampton | New York, New York | Curaçao | Manzanillo | Los Angeles, California | Los Angeles, California
11 Jan 2026
23 Nights
Queen Mary 2
Transatlantic
Fly Cruise From
Was £10299pp
Now: £10093 pp
REF: CUNARDM603E
Southampton to San Francisco
Southampton | New York, New York | Curaçao | Manzanillo | Los Angeles, California | Los Angeles, California | San Francisco, California | San Francisco, California
11 Jan 2026
26 Nights
Queen Mary 2
Transatlantic
Fly Cruise From
Was £11639pp
Now: £11406 pp
REF: CUNARDM603F
Tropical Escapades, East To West
Miami, Florida | Cartagena | Puntarenas | Corinto | Puerto Quetzal | Acapulco | Cabo San Lucas | Hilo, Hawaii | Kahului-Maui, Hawaii | Honolulu, Hawaii | Honolulu, Hawaii | Nawiliwili, Hawaii | Nawiliwili, Hawaii | Lahaina, Hawaii | More...
11 Jan 2026
35 Nights
Seven Seas Mariner
Panama Canal
Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
Fly Cruise From
Was £21854pp
Now: £20761 pp
REF: REGENTMAR260111A
Crossing Horizons
Miami, Florida | Cartagena | Puntarenas | Corinto | Puerto Quetzal | Acapulco | Cabo San Lucas | Hilo, Hawaii | Kahului-Maui, Hawaii | Honolulu, Hawaii | Honolulu, Hawaii
11 Jan 2026
21 Nights
Seven Seas Mariner
Panama Canal
Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
Fly Cruise From
Was £14599pp
Now: £13869 pp
REF: REGENTMAR260111
Tropical Tastes Of The Riviera
Panama City | Puntarenas | Corinto | Puerto Vallarta | Cabo San Lucas | Ensenada | Los Angeles, California
15 Jan 2026
10 Nights
Seven Seas Grandeur
South America
Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
Fly Cruise From
Was £6799pp
Now: £6459 pp
REF: REGENTGRA260115

Prices are subject to change and availability. Prices may vary depending on airport selected. Promotions are only applicable to select cabins grades, please call for details

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