Panama Canal Luxury Cruises

Browse all available sailing dates for luxury cruise holidays to the Panama Canal. To find out more and to discover the best deals call us today and speak to our cruise experts. All Pnama Canal cruise holidays are fully ABTA & ATOL protected.

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Stars & Salsa
Los Angeles, California | Cabo San Lucas | Acapulco | Puerto Quetzal | Corinto | Puntarenas | Cartagena | Georgetown, Grand Cayman | Miami, Florida
25 Jan 2026
16 Nights
Seven Seas Grandeur
Panama Canal
Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
EXCLUSIVE $400 FREE to spend on-board per couple
Fly Cruise From
Was £9239pp
Now: £8212 pp
REF: REGENTGRA260125
11 Nt Panama Canal & Southern Caribbean
Fort Lauderdale, Florida | Cartagena | Colón | Oranjestad | Willemstad | Georgetown, Grand Cayman | Fort Lauderdale, Florida
02 Feb 2026
11 Nights
Celebrity Ascent
Panama Canal
Fly Cruise From
Was £4186pp
Now: £3976 pp
REF: CELEBAT11C023-020226
13-Night Chile, Peru & Panama Voyage
San Antonio | Coquimbo | Iquique | Arica | Pisco | Callao | Callao | Fuerte Amador | Fuerte Amador
02 Mar 2026
13 Nights
Azamara Quest
South America
Balconies and above receive: $300 FREE to spend on-board, Premium beverage package & unlimited wi-fi*
Cruise Only From
Was £3309pp
Now: £3113 pp
REF: AZQS260302-013
48-Day Polynesia & Panama Canal Passage
Papeete, Tahiti | Papeete, Tahiti | Fakarava | Rangiroa | Huahine | Raiatea | Bora-Bora | Bora-Bora | Papeete, Tahiti | Moorea | Papeete, Tahiti | Raiatea | Bora-Bora | Kahului-Maui, Hawaii | More...
09 Mar 2026
48 Nights
Seabourn Quest
Panama Canal
Receive up to $2,200 to spend on-board per couple! - ENDS 3rd September
Cruise Only From
Was £17009pp
Now: £15029 pp
REF: SBN6622B
Ultimate Treasures of French Polynesia & South Pacific Islands
Lautoka | Savusavu | Neiafu | Alofi | Palmerston Island | Aitutaki | Bora-Bora | Huahine | Papeete, Tahiti | Papeete, Tahiti | Moorea | Rangiroa | Nuku Hiva Island | Atuona, Hiva Oa | More...
14 Mar 2026
30 Nights
Scenic Eclipse II
Pacific
Experience the voyage of a lifetime in 6-star ultra-luxury on board Scenic Eclipse, The World’s First Discovery Yachts
Fly Cruise From
Was £21044pp
Now: £20202 pp
REF: SCENIC182F140326-1
11-Night Caribbean Quest Voyage
Fuerte Amador | Cartagena | Santa Marta | Oranjestad | Kralendijk | Willemstad | Cabo Rojo | Miami, Florida
15 Mar 2026
11 Nights
Azamara Quest
Caribbean
Balconies and above receive: $300 FREE to spend on-board, Premium beverage package & unlimited wi-fi*
Cruise Only From

Now: £2559 pp
REF: AZQS260315-011
11 Nt Panama Canal & Southern Caribbean
Fort Lauderdale, Florida | Cartagena | Colón | Oranjestad | Willemstad | Kralendijk | Fort Lauderdale, Florida
16 Mar 2026
11 Nights
Celebrity Ascent
Panama Canal
Cruise Only From
Was £2657pp
Now: £2524 pp
REF: CELEBAT11C024-160326
38-Day Isles Of Polynesia, Hawaii & Panama Canal Passage
Papeete, Tahiti | Raiatea | Bora-Bora | Kahului-Maui, Hawaii | Honolulu, Hawaii | Kailua-Kona, Hawaii | Long Beach, California | Puerto Vallarta | Huatulco (Santa María Huatulco) | Puerto Chiapas | Puerto Quetzal | Puntarenas | Cartagena | Miami, Florida More...
19 Mar 2026
38 Nights
Seabourn Quest
Panama Canal
Receive up to $2,200 to spend on-board per couple! - ENDS 3rd September
Cruise Only From
Was £11699pp
Now: £10337 pp
REF: SBN6625A
Treasures of French Polynesia & the Marquesas Islands
Papeete, Tahiti | Moorea | Rangiroa | Nuku Hiva Island | Atuona, Hiva Oa | Cocos Island | Panama City | Panama City
25 Mar 2026
19 Nights
Scenic Eclipse II
Pacific
Experience the voyage of a lifetime in 6-star ultra-luxury on board Scenic Eclipse, The World’s First Discovery Yachts
Fly Cruise From
Was £11275pp
Now: £10824 pp
REF: SCENIC191F250326-1
Palms & Panama Canal
Tampa, Florida | Cozumel | Costa Maya | Belize City | Roatán Island | Puerto Limón | Colón | Panama City | Panama City
25 Mar 2026
10 Nights
Oceania Insignia
Panama Canal
FREE simply MORE shore excursion credit, FREE gratuities, FREE Champagne, wine and more, FREE speciality dining and FREE Wi-Fi available on EVERY booking
Fly Cruise From
Was £4509pp
Now: £4069 pp
REF: OCEANIAINS260325
Panama Canal Connoisseur
Tampa, Florida | Cozumel | Costa Maya | Belize City | Roatán Island | Puerto Limón | Colón | Panama City | Panama City | Cartagena | Willemstad | Oranjestad | Montego Bay | Georgetown, Grand Cayman | More...
25 Mar 2026
20 Nights
Oceania Insignia
Panama Canal
FREE simply MORE shore excursion credit, FREE gratuities, FREE Champagne, wine and more, FREE speciality dining and FREE Wi-Fi available on EVERY booking
Fly Cruise From
Was £6539pp
Now: £5901 pp
REF: OCEANIAINS260325A
Classic Canal & Tropics
Panama City | Cartagena | Willemstad | Oranjestad | Montego Bay | Georgetown, Grand Cayman | Miami, Florida
04 Apr 2026
10 Nights
Oceania Insignia
Panama Canal
HUGE savings, FREE Prestige Select Beverage Package worth $30pppd & FREE on-board spend - EXCLUSIVE to SixStarCruises
FREE simply MORE shore excursion credit, FREE gratuities, FREE Champagne, wine and more, FREE speciality dining and FREE Wi-Fi available on EVERY booking
Fly Cruise From
Was £4199pp
Now: £3789 pp
REF: OCEANIAINS260404
19-Day Panama Canal Passage
Long Beach, California | Puerto Vallarta | Huatulco (Santa María Huatulco) | Puerto Chiapas | Puerto Quetzal | Puntarenas | Cartagena | Miami, Florida
07 Apr 2026
19 Nights
Seabourn Quest
Panama Canal
Receive up to $2,200 to spend on-board per couple! - ENDS 3rd September
Cruise Only From
Was £5309pp
Now: £4691 pp
REF: SBN6626
Panama Canal & the Alluring Islands of the Caribbean
Panama City | Portobelo | Cayos Limon | Cartagena | Aruba | Curaçao | Curaçao | Tobago Cays | Bridgetown
13 Apr 2026
11 Nights
Scenic Eclipse II
Caribbean
Experience the voyage of a lifetime in 6-star ultra-luxury on board Scenic Eclipse, The World’s First Discovery Yachts
Fly Cruise From
Was £9093pp
Now: £8729 pp
REF: SCENIC121C130426-1
Vivid Western Caribbean
Miami, Florida | Cozumel | Costa Maya | Belize City | Roatán Island | Puerto Limón | Colón | Panama City | Panama City
14 Apr 2026
10 Nights
Oceania Insignia
Caribbean
FREE simply MORE shore excursion credit, FREE gratuities, FREE Champagne, wine and more, FREE speciality dining and FREE Wi-Fi available on EVERY booking
Fly Cruise From
Was £4289pp
Now: £3870 pp
REF: OCEANIAINS260414
Canal & Coral Isles
Panama City | Cartagena | Puerto Limón | Roatán Island | Costa Maya | Cozumel | Miami, Florida
24 Apr 2026
10 Nights
Oceania Insignia
Panama Canal
FREE simply MORE shore excursion credit, FREE gratuities, FREE Champagne, wine and more, FREE speciality dining and FREE Wi-Fi available on EVERY booking
Fly Cruise From
Was £4059pp
Now: £3663 pp
REF: OCEANIAINS260424
Costa Rica & the Panama Canal
San José | San José | Curú Wildlife Refuge | Manuel Antonio National Park | Punta Rio Claro National Wildlife Refuge | Golfo Dulce | Coiba Island | Coiba Island | Pearl Islands | Panama City | Panama City
28 Apr 2026
11 Nights
Sylvia Earle
Panama Canal
Cruise Only From
Was £8396pp
Now: £8144 pp
REF: AURORACRP006S
Ultimate America's Historic Journey to Panama
New York, New York | Wilmington, Delaware | Baltimore, Maryland | Yorktown, Virginia | Wilmington, North Carolina | Charleston, South Carolina | Miami, Florida | Key West, Florida | Nassau | Nassau | Staniel Cay | San Salvador Island | Cabo de la Vela | Cartagena | More...
05 Oct 2026
21 Nights
Scenic Eclipse
Panama Canal
Experience the voyage of a lifetime in 6-star ultra-luxury on board Scenic Eclipse, The World’s First Discovery Yachts
Fly Cruise From
Was £15240pp
Now: £14630 pp
REF: SCENIC902U051026-1
Pristine islands of the Bahamas & the Panama Canal
Nassau | Staniel Cay | San Salvador Island | Cabo de la Vela | Cartagena | San Blas Islands | Bocas del Toro | Panama City | Panama City
16 Oct 2026
10 Nights
Scenic Eclipse
Caribbean
Experience the voyage of a lifetime in 6-star ultra-luxury on board Scenic Eclipse, The World’s First Discovery Yachts
Fly Cruise From
Was £8434pp
Now: £8096 pp
REF: SCENIC111C161026-1
Wellness Retreat - Panama City to Valparaiso
Panama City | Valparaiso
26 Oct 2026
9 Nights
Scenic Eclipse
Panama Canal
Experience the voyage of a lifetime in 6-star ultra-luxury on board Scenic Eclipse, The World’s First Discovery Yachts
Fly Cruise From
Was £6914pp
Now: £6637 pp
REF: SCENIC801R261026-1
Panama Canal & Pacific Gems
Miami, Florida | Georgetown, Grand Cayman | Cartagena | Puntarenas | Corinto | Puerto Quetzal | Acapulco | Cabo San Lucas | San Diego, California | Los Angeles, California
29 Dec 2026
16 Nights
Seven Seas Grandeur
Panama Canal
Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
Fly Cruise From
Was £9759pp
Now: £8807 pp
REF: REGENTGRA261229
Navigate The World
Miami, Florida | Miami, Florida | Cozumel | Costa Maya | Harvest Caye | Roatán Island | Georgetown, Grand Cayman | Ocho Rios | Puerto Limón | Cartagena | Panama City | Panama City | Puntarenas | Corinto | More...
11 Jan 2027
127 Nights
Seven Seas Splendor
World-wide
Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
Fly Cruise From
Was £73224pp
Now: £66084 pp
REF: REGENTSPL270111F
World Of Splendor
Miami, Florida | Miami, Florida | Cozumel | Costa Maya | Harvest Caye | Roatán Island | Georgetown, Grand Cayman | Ocho Rios | Puerto Limón | Cartagena | Panama City | Panama City | Puntarenas | Corinto | More...
11 Jan 2027
141 Nights
Seven Seas Splendor
World-wide
Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
Fly Cruise From
Was £80244pp
Now: £72420 pp
REF: REGENTSPL270111G
Ultimate Panama Canal Transit
Los Angeles, California | Cabo San Lucas | Puerto Vallarta | Puerto Quetzal | Puntarenas | Cartagena | Georgetown, Grand Cayman | Miami, Florida
24 Jan 2027
16 Nights
Seven Seas Grandeur
Panama Canal
Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
Fly Cruise From
Was £9229pp
Now: £8329 pp
REF: REGENTGRA270124
Exotic Coasts & Casco Viejo
Miami, Florida | Costa Maya | Harvest Caye | Roatán Island | Georgetown, Grand Cayman | Ocho Rios | Puerto Limón | Cartagena | Colón | Panama City | Panama City
23 Feb 2027
14 Nights
Seven Seas Grandeur
South America
Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
Fly Cruise From
Was £8564pp
Now: £7729 pp
REF: REGENTGRA270223

Prices are subject to change and availability. Prices may vary depending on airport selected. Promotions are only applicable to select cabins grades, please call for details

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