Luxury South America Cruises

Luxury cruises in South America are all about the experience. Book one of the cruise deals below and you will have the opportunity to trek through wildlife-rich jungles, marvel at thundering waterfalls, visit ancient Incan ruins, and much more. Depending on the type of cruise you book, you may also get the chance to experience something truly unique, exclusively packaged up with luxury hotel stays and one-of-a-kind tours.

Find Out More About Cruising in South America


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Call Of The Amazon
Miami, Florida | Saint John's | Castries | Saint George's | Scarborough | Santarém | Boca de Valeria | Manaus | Manaus | Parintins | Alter do Chão | Bridgetown | Roseau | Philipsburg | More...
12 Nov 2025
25 Nights
South America

FREE simply MORE shore excursion credit, FREE gratuities, FREE Champagne, wine and more, FREE speciality dining and FREE Wi-Fi available on EVERY booking
Ends 30th September - Last chance to book and receive a FREE house select beverage package
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £6899pp
Now: £6226
pp
REF: OCEANIAINS251112
Magic of Colombia
Barranquilla | Nueva Venecia | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Calamar | Cartagena | Cartagena
15 Nov 2025
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £4892pp
Now: £4696
pp
REF: AMASA251115BC
San Cristóbal to San Cristóbal
San Cristóbal Island, Galápagos | Roca León Dormido | Bartolome Island | Santiago Island, Galápagos | Punta Vicente Roca, Isabela Island, Galápagos | Punta Espinoza, Fernandina Island, Galápagos | Elizabeth Bay, Isabela Island, Galápagos | Caleta Tagus | Champion Island, Galápagos | Post Office Bay, Floreana, Galápagos | Punta Cormorant, Floreana Island, Galápagos | Los Gemelos, Santa Cruz Island, Galápagos | Puerto Ayora, Isla Santa Cruz | Santa Cruz Island, Galápagos | More...
15 Nov 2025
7 Nights
Pacific

Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £10600pp
Now: £9566
pp
REF: SILVEROR251115007
10-Day The Great White Continent
Buenos Aires | Ushuaia | Antarctic Experience | Antarctic Experience | Antarctic Experience | Antarctic Experience | Antarctic Experience | Buenos Aires | Ushuaia
16 Nov 2025
11 Nights
Antarctica

EXCLUSIVE $600 to spend on-board* - must end 23rd September
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £7393pp
Now: £6532
pp
REF: SBNP555
7 Night Galapagos Outer Loop Cruise
Baltra Island, Galápagos | Punta Suarez, Isla Española, Galápagos | Gardner Bay, Española Island, Galápagos | Floreana Island, Galapagos | Punta Cormorant, Floreana Island, Galápagos | Elizabeth Bay, Isabela Island, Galápagos | Urbina Bay, Isabella Island, Galapagos | Vincente Roca Point, Isabella Island, Galapagos | Punta Espinoza, Fernandina Island, Galápagos | Daphne Major, Galapagos | South Plaza Island, Galápagos | Dragon Hill, Santa Cruz Island, Galápagos | Puerto Ayora, Isla Santa Cruz | Baltra Island, Galápagos More...
16 Nov 2025
7 Nights
Pacific

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £7686pp
Now: £6203
pp
REF: CELEBFL07G056-161125
Southern Caribbean Beauty
Miami, Florida | Cozumel | Costa Maya | Harvest Caye | Roatán Island | Puerto Limón | Colón | Cartagena | Cartagena | Oranjestad | Willemstad | Kralendijk | Saint George's | Bridgetown More...
17 Nov 2025
16 Nights
Caribbean

Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
EXCLUSIVE $400 FREE to spend on-board per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £8669pp
Now: £7823
pp
REF: REGENTSPL251117
Caribbean Shores To Rio's Marvels
Miami, Florida | Cozumel | Costa Maya | Harvest Caye | Roatán Island | Puerto Limón | Colón | Cartagena | Cartagena | Oranjestad | Willemstad | Kralendijk | Saint George's | Bridgetown | More...
17 Nov 2025
30 Nights
Caribbean

Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £16599pp
Now: £14980
pp
REF: REGENTSPL251117A
Wonders of Colombia
Cartagena | Palenque | Calamar | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Barranquilla | Nueva Venecia | Barranquilla
19 Nov 2025
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £4892pp
Now: £4696
pp
REF: AMASB251119CB
Antarctica Active: All Inclusive Activities
Ushuaia | Ushuaia | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Ushuaia
20 Nov 2025
14 Nights
Antarctica

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £11312pp
Now: £10972
pp
REF: AURORAAPD004G
15 Nt Portugal, Argentina Transatlantic
Lisbon | Tenerife | Salvador de Bahia | Rio de Janeiro | Montevideo | Buenos Aires
21 Nov 2025
15 Nights
Transatlantic

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £3303pp
Now: £2973
pp
REF: CELEBEQ15T231-211125
Antarctica, South Georgia & Falkland Islands
Buenos Aires | Buenos Aires | Ushuaia | Falkland Islands | Falkland Islands | South Georgia Island | South Georgia Island | South Georgia Island | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Ushuaia | More...
22 Nov 2025
19 Nights
Antarctica

Celebrate 5 years of Scenic Ocean with an ADDITIONAL 5% off ALL sailings - Call for your extra savings
Save up to 30%, return flights included and free private door to door transfers*
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £21992pp
Now: £18902
pp
REF: SCENIC201S221125-1
Wonders of Colombia
Cartagena | Palenque | Calamar | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Barranquilla | Nueva Venecia | Barranquilla
22 Nov 2025
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £5598pp
Now: £5153
pp
REF: AMASA251122CB
Puerto Williams to Puerto Williams
Puerto Williams | Antarctic Sound | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | South Shetland Islands | Puerto Williams | Puerto Williams
22 Nov 2025
10 Nights
Antarctica

Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £14300pp
Now: £12905
pp
REF: SILVEREV251122010
Bridgetown to Cartagena
Bridgetown | Soufrière | Port Elizabeth, Bequia | Kralendijk | Willemstad | Oranjestad | Oranjestad | Santa Marta | Cartagena
22 Nov 2025
9 Nights
Caribbean

Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £6100pp
Now: £5505
pp
REF: SILVERSS251122009
7 Night Galapagos Inner Loop Cruise
Baltra Island, Galápagos | Rabida Island | Puerto Egas | Elizabeth Bay, Isabela Island, Galápagos | Tagus Cove, Isabella Island, Galapagos | Bartolome Island | Sullivan Bay, Santiago Island, Galápagos | Daphne Major, Galapagos | North Seymour Island, Galapagos | Las Bachas, Santa Cruz Island, Galápagos | Punta Pitt, San Cristóbal Island, Galápagos | Puerto Baquerizo Moreno, San Cristobal Island, Galapagos | Puerto Ayora, Isla Santa Cruz | Baltra Island, Galápagos More...
23 Nov 2025
7 Nights
Pacific

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £10217pp
Now: £9318
pp
REF: CELEBFL07G055-231125
Puerto Williams to Puerto Williams
Puerto Williams | New Island | West Point Island | Port Stanley | South Georgia Island | South Georgia Island | South Georgia Island | Elephant Island, South Shetland Islands | Antarctic Sound | Antarctic Peninsula | Antarctic Peninsula | South Shetland Islands | Puerto Williams | Puerto Williams More...
23 Nov 2025
18 Nights
Antarctica

Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £19600pp
Now: £17689
pp
REF: SILVERWI251123018
Yucatan Gems & Serene Isles
Miami, Florida | Costa Maya | Harvest Caye | Roatán Island | Cozumel | Miami, Florida | San Juan (Puerto Rico) | Gustavia | Santa Marta | Frederiksted, Saint Croix | Punta Cana | Nassau | Miami, Florida
24 Nov 2025
17 Nights
Caribbean

Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £9919pp
Now: £8951
pp
REF: REGENTGRA251124A
22-Day Panama Canal Passage
Miami, Florida | Catalina Island | Curaçao | Santa Marta | Golfito | Puntarenas | Puerto Quetzal | Puerto Chiapas | Huatulco (Santa María Huatulco) | Cabo San Lucas | Los Angeles, California
25 Nov 2025
22 Nights
Panama Canal

EXCLUSIVE $600 to spend on-board* - must end 23rd September
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £8369pp
Now: £7394
pp
REF: SBN5563
42-Day Panama Canal & Hawaiian Holiday
Miami, Florida | Catalina Island | Curaçao | Santa Marta | Golfito | Puntarenas | Puerto Quetzal | Puerto Chiapas | Huatulco (Santa María Huatulco) | Cabo San Lucas | Los Angeles, California | Honolulu, Hawaii | Honolulu, Hawaii | Hilo, Hawaii | More...
25 Nov 2025
42 Nights
Panama Canal

EXCLUSIVE $600 to spend on-board* - must end 23rd September
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £14489pp
Now: £12802
pp
REF: SBN5563A
7-Night Ushuaia to King George Island
Ushuaia | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | South Shetland Islands | King George Island, South Shetland Islands
25 Nov 2025
7 Nights
Antarctica

ALWAYS INCLUDED: cultural immersion, gourmet dining, unlimited beverages, including fine wines, spirits and craft beers, stocked in-room minibar, 24-hour room service, pre-paid gratuities PLUS MUCH MORE!
Polar Expedition
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From

Now: £9019
pp
REF: ATLASVOYWV0073-WVO251125
Magic of Colombia
Barranquilla | Nueva Venecia | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Calamar | Cartagena | Cartagena
26 Nov 2025
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £5030pp
Now: £4829
pp
REF: AMASB251126BC
10-Day The Great White Continent
Buenos Aires | Ushuaia | Antarctic Experience | Antarctic Experience | Antarctic Experience | Antarctic Experience | Antarctic Experience | Buenos Aires | Ushuaia
26 Nov 2025
11 Nights
Antarctica

EXCLUSIVE $600 to spend on-board* - must end 23rd September
Sail into Savings - Save up to 15% on selected Ocean and Expedition Voyages
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £7563pp
Now: £6682
pp
REF: SBNP556
Puerto Williams to Puerto Williams
Puerto Williams | Antarctic Sound | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | South Shetland Islands | Puerto Williams | Puerto Williams
26 Nov 2025
10 Nights
Antarctica

Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £13200pp
Now: £11913
pp
REF: SILVERE4251126010
Fort Lauderdale round-trip
Fort Lauderdale, Florida | Georgetown, Grand Cayman | Montego Bay | Santo Domingo | San Juan (Puerto Rico) | Marigot | Fort-de-France | Bridgetown | Saint George's | Kralendijk | Willemstad | Oranjestad | Cartagena | Cartagena | More...
28 Nov 2025
24 Nights
Caribbean

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £8550pp
Now: £8293
pp
REF: CRYSTALCSE-C24-251128
Lisbon to Rio de Janeiro
Lisbon | Funchal, Madeira | Funchal, Madeira | Santa Cruz de La Palma | Mindelo, São Vicente Island | Recife | Salvador de Bahia | Rio de Janeiro | Rio de Janeiro
28 Nov 2025
18 Nights
Transatlantic

$300 FREE to spend on-board - ONLY when booking with SixStarCruises
Save £2400 per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £6500pp
Now: £5866
pp
REF: SILVERWH251128018

Explore South America on a Finest Collection voyage

Our Finest Collection cruise packages in South America offer tailor-made adventures exclusively for you. Your cruise is paired with a set of immersive land tours dedicated to helping you get right to the heart of the ports on your itinerary. What's more, after days spent hiking across glaciers or exploring iconic cities accompanied by a local tour guide, you can retire to a five-star hotel for a gourmet dinner and spot of well-earned relaxation. 

South America expedition cruises

If you want your South America cruise adventure to be even more unforgettable, embark on an expedition cruise and feel like a true explorer. Sailing to destinations like mysterious Easter Island, wild and rugged Chile, and the positively prehistoric Galapagos islands; once-in-a-lifetime experiences are guaranteed. Accompanied by a dedicated group of expedition experts - from marine biologists to professional adventurers - you willl live like an intrepid explorer and witness natural wonders most people can only dream of.

Book South America cruises with our Cruise Concierge team

If you would like to embark on an adventure you will never forget, call our Cruise Concierge team to book one of the itineraries below. And if you can't find exactly what you are looking for? Call us to build a completely bespoke cruise in South America that incorporates every port and experience you have been dreaming of.

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