Luxury South America Cruises

Luxury cruises in South America are all about the experience. Book one of the cruise deals below and you will have the opportunity to trek through wildlife-rich jungles, marvel at thundering waterfalls, visit ancient Incan ruins, and much more. Depending on the type of cruise you book, you may also get the chance to experience something truly unique, exclusively packaged up with luxury hotel stays and one-of-a-kind tours.

Find Out More About Cruising in South America


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Secrets Of The Amazon
Miami, Florida | Bridgetown | Port-of-Spain | Macapa | Santarém | Boca de Valeria | Manaus | Parintins | Alter do Chão | Macapa | Saint George's | San Juan (Puerto Rico) | Miami, Florida
09 Nov 2026
22 Nights
South America

Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £10534pp
Now: £9506
pp
REF: REGENTMAR261109
Antarctica, South Georgia & Falkland Islands
Buenos Aires | Falkland Islands | Falkland Islands | South Georgia Island | South Georgia Island | South Georgia Island | South Georgia Island | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Ushuaia | Buenos Aires | More...
10 Nov 2026
21 Nights
Atlantic Islands

Celebrate 5 years of Scenic Ocean with an ADDITIONAL 5% off ALL sailings - Call for your extra savings
Save up to 30%, return flights included and free private door to door transfers*
Complimentary helicopter flightseeing on 26/27 Antarctica Voyages
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £24221pp
Now: £23252
pp
REF: SCENIC311S101126-1
Magic of Colombia
Barranquilla | Nueva Venecia | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Calamar | Cartagena | Cartagena
11 Nov 2026
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £4938pp
Now: £4740
pp
REF: AMASB261111BC
Magic of Colombia
Barranquilla | Nueva Venecia | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Calamar | Cartagena | Cartagena
14 Nov 2026
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £4938pp
Now: £4740
pp
REF: AMASA261114BC
Antarctica, South Georgia & Falkland Islands
Buenos Aires | Buenos Aires | Ushuaia | Falkland Islands | Falkland Islands | South Georgia Island | South Georgia Island | South Georgia Island | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Ushuaia | More...
15 Nov 2026
19 Nights
Antarctica

Celebrate 5 years of Scenic Ocean with an ADDITIONAL 5% off ALL sailings - Call for your extra savings
Save up to 30%, return flights included and free private door to door transfers*
Complimentary helicopter flightseeing on 26/27 Antarctica Voyages
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £22970pp
Now: £22051
pp
REF: SCENIC201S151126-1
7 Night Galapagos Outer Loop Cruise
Baltra Island, Galápagos | Punta Suarez, Isla Española, Galápagos | Gardner Bay, Española Island, Galápagos | Floreana Island, Galapagos | Punta Cormorant, Floreana Island, Galápagos | Elizabeth Bay, Isabela Island, Galápagos | Urbina Bay, Isabella Island, Galapagos | Vincente Roca Point, Isabella Island, Galapagos | Punta Espinoza, Fernandina Island, Galápagos | Daphne Major, Galapagos | South Plaza Island, Galápagos | Dragon Hill, Santa Cruz Island, Galápagos | Puerto Ayora, Isla Santa Cruz | Baltra Island, Galápagos More...
15 Nov 2026
7 Nights
Pacific

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £6429pp
Now: £5863
pp
REF: CELEBFL07G058-151126
Wonders of Colombia
Cartagena | Palenque | Calamar | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Barranquilla | Nueva Venecia | Barranquilla
18 Nov 2026
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £4938pp
Now: £4740
pp
REF: AMASB261118CB
Wonders of Colombia
Cartagena | Palenque | Calamar | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Barranquilla | Nueva Venecia | Barranquilla
21 Nov 2026
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £4938pp
Now: £4740
pp
REF: AMASA261121CB
7 Night Galapagos Inner Loop Cruise
Baltra Island, Galápagos | Rabida Island | Puerto Egas | Elizabeth Bay, Isabela Island, Galápagos | Tagus Cove, Isabella Island, Galapagos | Bartolome Island | Sullivan Bay, Santiago Island, Galápagos | Daphne Major, Galapagos | North Seymour Island, Galapagos | Las Bachas, Santa Cruz Island, Galápagos | Punta Pitt, San Cristóbal Island, Galápagos | Puerto Baquerizo Moreno, San Cristobal Island, Galapagos | Puerto Ayora, Isla Santa Cruz | Baltra Island, Galápagos More...
22 Nov 2026
7 Nights
Pacific

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £7169pp
Now: £6538
pp
REF: CELEBFL07G057-221126
Magic of Colombia
Barranquilla | Nueva Venecia | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Calamar | Cartagena | Cartagena
25 Nov 2026
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £4938pp
Now: £4740
pp
REF: AMASB261125BC
Magic of Colombia
Barranquilla | Nueva Venecia | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Calamar | Cartagena | Cartagena
28 Nov 2026
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £5012pp
Now: £4812
pp
REF: AMASA261128BC
7 Night Galapagos Outer Loop Cruise
Baltra Island, Galápagos | Punta Suarez, Isla Española, Galápagos | Gardner Bay, Española Island, Galápagos | Floreana Island, Galapagos | Punta Cormorant, Floreana Island, Galápagos | Elizabeth Bay, Isabela Island, Galápagos | Urbina Bay, Isabella Island, Galapagos | Vincente Roca Point, Isabella Island, Galapagos | Punta Espinoza, Fernandina Island, Galápagos | Daphne Major, Galapagos | South Plaza Island, Galápagos | Dragon Hill, Santa Cruz Island, Galápagos | Puerto Ayora, Isla Santa Cruz | Baltra Island, Galápagos More...
29 Nov 2026
7 Nights
Pacific

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £7188pp
Now: £6555
pp
REF: CELEBFL07G058-291126
Riviera Chic & Caribbean Cool
Miami, Florida | San Juan (Puerto Rico) | Gustavia | Santa Marta | Frederiksted, Saint Croix | La Romana | Nassau | Miami, Florida
29 Nov 2026
10 Nights
Caribbean

Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
EXCLUSIVE $400 FREE to spend on-board per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £5654pp
Now: £5102
pp
REF: REGENTGRA261129
Antarctica in Depth
Buenos Aires | Buenos Aires | Ushuaia | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Ushuaia | Buenos Aires | Ushuaia
30 Nov 2026
12 Nights
Antarctica

Celebrate 5 years of Scenic Ocean with an ADDITIONAL 5% off ALL sailings - Call for your extra savings
Save up to 30%, return flights included and free private door to door transfers*
Complimentary helicopter flightseeing on 26/27 Antarctica Voyages
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £16858pp
Now: £16184
pp
REF: SCENIC101S301126-1
Wonders of Colombia
Cartagena | Palenque | Calamar | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Barranquilla | Nueva Venecia | Barranquilla
02 Dec 2026
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £5012pp
Now: £4812
pp
REF: AMASB261202CB
Antarctica and the Weddell Sea
Buenos Aires | Buenos Aires | Ushuaia | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Ushuaia | More...
03 Dec 2026
15 Nights
Antarctica

Celebrate 5 years of Scenic Ocean with an ADDITIONAL 5% off ALL sailings - Call for your extra savings
Save up to 30%, return flights included and free private door to door transfers*
Complimentary helicopter flightseeing on 26/27 Antarctica Voyages
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £16691pp
Now: £16023
pp
REF: SCENIC501S031226-1
Wonders of Colombia
Cartagena | Palenque | Calamar | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Barranquilla | Nueva Venecia | Barranquilla
05 Dec 2026
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £5085pp
Now: £4882
pp
REF: AMASA261205CB
7 Night Galapagos Inner Loop Cruise
Baltra Island, Galápagos | Rabida Island | Puerto Egas | Elizabeth Bay, Isabela Island, Galápagos | Tagus Cove, Isabella Island, Galapagos | Bartolome Island | Sullivan Bay, Santiago Island, Galápagos | Daphne Major, Galapagos | North Seymour Island, Galapagos | Las Bachas, Santa Cruz Island, Galápagos | Punta Pitt, San Cristóbal Island, Galápagos | Puerto Baquerizo Moreno, San Cristobal Island, Galapagos | Puerto Ayora, Isla Santa Cruz | Baltra Island, Galápagos More...
06 Dec 2026
7 Nights
Pacific

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £7188pp
Now: £6555
pp
REF: CELEBFL07G057-061226
Magic of Colombia
Barranquilla | Nueva Venecia | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Calamar | Cartagena | Cartagena
09 Dec 2026
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £5085pp
Now: £4882
pp
REF: AMASB261209BC
Antarctica in Depth
Buenos Aires | Buenos Aires | Ushuaia | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Ushuaia | Buenos Aires | Ushuaia
11 Dec 2026
12 Nights
Antarctica

Celebrate 5 years of Scenic Ocean with an ADDITIONAL 5% off ALL sailings - Call for your extra savings
Save up to 30%, return flights included and free private door to door transfers*
Complimentary helicopter flightseeing on 26/27 Antarctica Voyages
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £16395pp
Now: £14377
pp
REF: SCENIC101S111226-1
Tropical Sparkle & Holiday Cheer
Galveston, Texas | Montego Bay | Port Royal | Punta Cana | San Juan (Puerto Rico) | Tortola | Saint John's | Gustavia | Santa Marta | Georgetown, Grand Cayman | Galveston, Texas
11 Dec 2026
17 Nights
Caribbean

Ultimate All-Inclusive Cruise Fare now includes: Round-trip Economy flights, transfers between airport and ship PLUS Private Executive Chauffeur Credit*
EXCLUSIVE $400 FREE to spend on-board per couple
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £9094pp
Now: £8207
pp
REF: REGENTSPL261211
Magic of Colombia
Barranquilla | Nueva Venecia | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Calamar | Cartagena | Cartagena
12 Dec 2026
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £5085pp
Now: £4882
pp
REF: AMASA261212BC
7 Night Galapagos Outer Loop Cruise
Baltra Island, Galápagos | Punta Suarez, Isla Española, Galápagos | Gardner Bay, Española Island, Galápagos | Floreana Island, Galapagos | Punta Cormorant, Floreana Island, Galápagos | Elizabeth Bay, Isabela Island, Galápagos | Urbina Bay, Isabella Island, Galapagos | Vincente Roca Point, Isabella Island, Galapagos | Punta Espinoza, Fernandina Island, Galápagos | Daphne Major, Galapagos | South Plaza Island, Galápagos | Dragon Hill, Santa Cruz Island, Galápagos | Puerto Ayora, Isla Santa Cruz | Baltra Island, Galápagos More...
13 Dec 2026
7 Nights
Pacific

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Cruise Only From
Was £7188pp
Now: £6555
pp
REF: CELEBFL07G058-131226
Wonders of Colombia
Cartagena | Palenque | Calamar | Pinto | Santa Cruz de Mompox | Santa Cruz de Mompox | Santa Cruz de Mompox | El Banco | Magangué | Barranquilla | Nueva Venecia | Barranquilla
16 Dec 2026
7 Nights
South America

SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £5085pp
Now: £4882
pp
REF: AMASB261216CB
Antarctica in Depth
Buenos Aires | Buenos Aires | Ushuaia | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Antarctic Peninsula | Ushuaia | Buenos Aires | Ushuaia
17 Dec 2026
12 Nights
Antarctica

Celebrate 5 years of Scenic Ocean with an ADDITIONAL 5% off ALL sailings - Call for your extra savings
Save up to 30%, return flights included and free private door to door transfers*
Complimentary helicopter flightseeing on 26/27 Antarctica Voyages
SixStarCruises FLASH SALE - Save up to an EXTRA £300* off advertised prices
Fly Cruise From
Was £16858pp
Now: £16184
pp
REF: SCENIC101S171226-1

Explore South America on a Finest Collection voyage

Our Finest Collection cruise packages in South America offer tailor-made adventures exclusively for you. Your cruise is paired with a set of immersive land tours dedicated to helping you get right to the heart of the ports on your itinerary. What's more, after days spent hiking across glaciers or exploring iconic cities accompanied by a local tour guide, you can retire to a five-star hotel for a gourmet dinner and spot of well-earned relaxation. 

South America expedition cruises

If you want your South America cruise adventure to be even more unforgettable, embark on an expedition cruise and feel like a true explorer. Sailing to destinations like mysterious Easter Island, wild and rugged Chile, and the positively prehistoric Galapagos islands; once-in-a-lifetime experiences are guaranteed. Accompanied by a dedicated group of expedition experts - from marine biologists to professional adventurers - you willl live like an intrepid explorer and witness natural wonders most people can only dream of.

Book South America cruises with our Cruise Concierge team

If you would like to embark on an adventure you will never forget, call our Cruise Concierge team to book one of the itineraries below. And if you can't find exactly what you are looking for? Call us to build a completely bespoke cruise in South America that incorporates every port and experience you have been dreaming of.

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